After the setup of ISPConfig and the transfer of all out client domains and mail accounts, I noticed that Mambo and other db applications don't want to run properly. Eventually I tracked the problem to the VHosts_ispconfig.conf file where it keeps adding two directives to all new virtual hosts added on the site. I amanually editied this file to comment out the two directives that was preventing Mambo to run # php_admin_flag safe_more On # php_admin_value open_basedit /var/www/web??/ This then works fine untill I open ISPConfig and make any change on any of the domain, as it seems that ISPCOnfig then re-writes the VHosts_ispconfig.conf and removed the comments from all the sites to have php safe_mode on again and the open_basedit restriction on again for all the virtual domains. How to I stop this from happening, and maybe even if possible disable thise to directives on all current websites as well as future websites to be added?