I made a fresh install of Ubuntu with ispconfig following the tutorial. As I only need Web and DB I skipped everything regarding email and dns. Also I did not install FTP. The server is running only one website is active and the server is only used from two persons that work on the website. So the performance should always be very good. Randomly some pages are very slow. It may take about 10 seconds until a page loads, which normaly loads in less then one second. I see that it takes a long time to do the TLS-Handshake. The website runs with php-fpm. I also tried fast-cgi, but not really a difference. In the error log of the webiste there is nothing. In the global error log i can find these errors: When using fast-cgi a also get: This is strange because at that time I was the only person connecting to the server and only called one or two pages. Python is not used in the website only php. I cannot see anything about the slow TLS-Handshake. Any ideas?