So I got a notification that my self-signed ssl cert for localhost is about to expire. I copied my /etc/pki/tls to another folder and ran genkey. Once the process was completed I rebooted. ISPCONFIG web interface comes up but now of the websites are up. I renamed my tls folder tls.new and renamed the old one tls. Rebooted again and everything seems fine. Other than my cert is getting ready to expire. Any ideas?