Have a multiserver setup and installed a new webserver that includes having roundcube installed on it using: https://www.howtoforge.com/using-roundcube-webmail-with-ispconfig-3-on-debian-wheezy-apache2 I can access webmail using the server name, but not when using a domain that is on that server http://servername.com/webmail <- I get the roundcube login screen http://my_domain.com/webmail <- get a 500 error Looking at the error log for the website I see these errors: [Wed Aug 12 13:06:28 2015] [error] [client 76.xx.xx.24] PHP Warning: require_once(): open_basedir restriction in effect. File(/usr/share/roundcube/program/include/iniset.php) is not within the allowed path(s): (/var/www/clients/client66/web187/web:/var/www/clients/client66/web187/private:/var/www/clients/client66/web187/tmp:/var/www/domainguyz.com/web:/srv/www/domainguyz.com/web:/usr/share/php5:/usr/share/php:/tmp:/usr/share/phpmyadmin:/etc/phpmyadmin:/var/lib/phpmyadmin) in /usr/share/roundcube/index.php on line 31 [Wed Aug 12 13:06:28 2015] [error] [client 76.xx.xx.24] PHP Warning: require_once(/usr/share/roundcube/program/include/iniset.php): failed to open stream: Operation not permitted in /usr/share/roundcube/index.php on line 31 [Wed Aug 12 13:06:28 2015] [error] [client 76.xx.xx.24] PHP Fatal error: require_once(): Failed opening required 'program/include/iniset.php' (include_path='.:/usr/share/php') in /usr/share/roundcube/index.php on line 31 Don't remember ever seeing this error before. Any idea where to start looking to fix this? Thanks!!!