I am now trying to install ispconfig3 following this guide: https://www.howtoforge.com/perfect-server-debian-10-nginx-bind-dovecot-ispconfig-3.1/ It should be possible the only with a few problems 9 Install Amavisd-new, SpamAssassin, and ClamAV To install amavisd-new, SpamAssassin, and ClamAV, we run: apt-get install amavisd-new spamassassin clamav clamav-daemon unzip bzip2 arj nomarch lzop cabextract p7zip p7zip-full unrar lrzip apt-listchanges libnet-ldap-perl libauthen-sasl-perl clamav-docs daemon libio-string-perl libio-socket-ssl-perl libnet-ident-perl zip libnet-dns-perl libdbd-mysql-perl postgrey Here the unrar was not available in the repository else every step was succesfull so maybe not a big problem maybe. Then I keep on following the guide and it looks fine until step 11 11 Install Let's Encrypt ISPConfig 3.1 has support for the free SSL Certificate authority Let's encrypt. The Let's Encrypt function allows you to create free SSL certificates for your website from within ISPConfig. cd /usr/local/bin wget https://dl.eff.org/certbot-auto chmod a+x certbot-auto ./certbot-auto --install-only I did the above but it complains and says: Certbot has problem setting up the virtual environment. We were not be able to guess the right solution from your pip output. Consult https://certbot.eff.org/docs/install.html#problems-with-python-virtual-environment for possible solutions. You may also find some support resources at https://certbot.eff.org/support/ I looks like I can do a like on ubunto and debian apt-get install certbot But would that be the same or is there a reason to do it like in the guide it looks like cerbot is installed so maybe should just carry on ?