The apache config file is ok. There is a problem with the ispconfig mysql user, this can be caused e.g.: a) The password of the user "ispconfig" was manually changed in mysql. If thats the case, undo the change. b) You did not use the mysql "root" user to install ispconfig, in this case, ispconfig has to be reinstalled (just ispconfig, not the whole server). c) Mysql is not started.