I have created some alias domain. After this shows red circle with number like it should be. But before it disappeared I have deleted this alias and then I have created it again. After this apache was stopped/crashed, because he couldn't find error.log file under /var/log/ispconfig/httpd/alias.domain.com/error.log. I couldn't create this file manually. I had to restart the server, because I couldn't start apache anyway. PS Of course, when I do things like above a little slower, when red circle disappear, then all work perfect.