I came here searching for info about the very same message.
ISPConfig-2.2.6 on debian sarge.
This is what happened: I tried to move a web from the (admin)/ispManager/ISP Site - tab by selecting a different entry in the Group - dropdown -control. Then saved.
Since then I can not change any value of the web in question, I receive a message:
"Your changes cannot be saved because this item is currently being updated. Please try again later."
Waiting didnt help, though.
ls -la /root/ispconfig/ showed no lock-file.
The ispconfig.log in /home/admispconfig only lists the messages.
Restarting the ispconfig_server didn't help either.