Thanks for the response. Here is the deal:
1. phpMyAdmin won't work as root or by the domain, which is the only website on this box
2. phpMyAdmin won't work period. Not as webserver.example.com:8080 (ISPConfig), or domain through ISPConfig, or through domain.com/phpmyadmin - All of these same error that I sent w/ 500 Internal Server Error
3. This box has about 50 websites, and there are two domains that can't be accessed (one of these is the webserver domain and a website) and another that gets the same exact error 500 Internal using url access or through ISPConfig...