I seem to remember I tested it with suphp a while back without problem, but I was doing a lot of testing and switching with suPHP and SuExec at the time, so I can't be certain.
I don't think it should be an issue, does suPHP really care what the underlying transport is?
I would have thought that browser support for SNI would be a far bigger issue. If 80% or whatever of people connecting use browsers able to support SNI, is it wise to implement it?
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