I don't know if this is causing problems, but you have
and
in your /etc/proftpd.conf. The first one is wrong, so I'd remove it and restart Proftpd.
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Also there are many entries where a session opens and closes (about every 30 minutes). Is this correct?
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This must be ISPConfig's monitoring script which tries to connect to your FTP server to see if it's still running. This is absolutely ok.