root@jfo:~# httpd -t
Syntax error on line 200 of /etc/apache2/vhosts/Vhosts_ispconfig.conf:
Invalid command 'safe_mode', perhaps mis-spelled or defined by a module not included in the server configuration
What's in line 200 of /etc/apache2/vhosts/Vhosts_ispconfig.conf? IT should contain
php_admin_flag safe_mode On
php_admin_flag safe_mode Off
not just safe_mode...