If there was a comment sign, this function was already deactivated. Please undo your changes in the php.ini files. Please bever edit the file /root/ispconfig/php/php.ini if you wont break ISPConfig!
As open_basedir was disbled already, please do waht I posted above:
If this is a website created in ISPCOnfig, then you will have to disable the php safemode checkbox for it.