I'd tried something. After a while I'd deleted the www A Record from typo3.home. NOW http://typo3.home works, but why? Maybe that bind don't like more than one A Record with the same name for the same IP. That's my mind. But how can i solve that Problem?
You can have as many A-Records for the IP as you like. Please check your syslog or messages log for errors.
Also hav a look in the ISPConfig logfile /home/admispconfig/ispconfig/ispconfig.log