You can install roundcube using the apps vhost, so every user can access roundcube (or everything you install there) in this way:
domain1.com:8081/roundcube
domain2.com:8081/roundcube
Software installed in the apps directory /var/www/apps must be owned by the user and group ispapps
Please note that /var/www/apps is the location in debian/ubuntu and I can't assume the location in centos for example.
Another option is create the subdomain webmail for each domain and redirect it to the desired location.
Cheers!
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