squirrelmail is not required to use email accounts with external mail clients like outlook or thudnerbird.
Btw, you dont have to disable squirrelmail to use ispconfig mail. I guess you just used a wrong alias for squirrelmail, the correct alias is /webmail while the wriong alias would be /mail. Edit the squirremail configuration file and set the alis to /webmail as described in the perfect setup guides.
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