Ohh.. I got it.
I check the php files again.
php -q /var/www/clients/client5/web5/web/member/services.php 'mailer'
The previous setting in ISPConfig:
It should be:
Because it's not configured to run cron from URL.
This cron job is one of my friend request, but I try to run it with ISPConfig system, and it works now.
Thanks for the ISPConfig developers.
I love you all..