Thats most likely the reason for your problems as the nginx implementation requires the software versions from Ubuntu 11.10 for several software packes like php, fcgiwrap,nginx and maybe others. For that reason we have not published a guide for debian 6 and Ubuntu 10.04.
If you like to use nginx with ISPConfig 3 you should use Ubuntu 11.10 as 10.04 is not supported for nginx.
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