Ispconfig uses the standard ports for email and also the standard encryption methods like tls, so thre is no need to change any settings in your mail client. But there is a known bug in the thunderbird setup whizard which might cause yor problem. Thunderbird removes the part after the @ in the username during initial setup. To fix this, go to account settings in thunderbird, edit the smtp settings and add the missing part in the smtp username.
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