You can restrict the access to the database to the IP of the web server by entering the IP address of the webserver(s) that shall be able to access this database into the "Remote Access IP's" field.
For performance reasons, I recommend that you run the database locally on the same server then the websites. In that case, the sites can connect to mysql trogh a local server socket instaed of tcpip which is faster and need less resources.
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