I think a short summary of the most tricky topics for people who already have some experience but are not familiar with ISC would be sufficent.
- IP settings for the server
- DNS server settings
- DNS settings for sites
- where to adjust vhost.conf
- where to setup cron jobs
- how to authorize external access to mysql databases (over a port)
- explanation of settings for running PHP as cgi, fast cgi, mod...