There are very good installation manuals for ispconfig 3 available. These manuals instruct you to install pure-ftpd and not proftpd, so the conclusion is that proftpd is not supported by ispconfig 3.
ISPConfig 3 supports ip based and namebased vhosts. as long as you have enough ip addresses you can access the sites by ip, but you will have to assign them at least some temorary or subdomain.
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