Thank you for your response, Till, but the error was in the sender server sending the messages.
I prove accounts in other server to point to my ISPCong accounts, and all sender and work very fine.
ISPConfig 3 Work very well for my and your works its very very well
Thanks for your help and sorry for the nuisances.
ISPConfig V.3 the best in the world.
Thanks to Till, Falko and any contributors.