1) ISPConfig 3 itself does not use any permanent system resources as it is no deamon, system rsources are only used when you access the interface or when a configuration seting is saved. So you will have to plan with the ressources that you need for your other servuces and that depends on the number of email and pageviews you expect.
2) Partitioning like this does not bring much benefit. If you want to use several vps for security resaons then make one vps for web + db + dns and anothet for postfix.
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