From your description my config should have already updated and it's not.
Can you give me some pointers to start looking for what caused this issue?
I have checked the ISPC log and have found it empty. Is there a way to enable verbose logging for ISPC3?
Also, since ISPC3 has the ability to apply additional apache directives, does ISPC3 do an 'apache2ctl -t' check before applying the configuration?
If not, should this be a feature request to parse the output of 'apache2ctl -t' before reloading Apache2 and notify you of the (error)s?
Just a few thoughts...