Hi there!!

 In order to make available the users profiles when using friendly URLs (www.mysite.com/user/theuser) we need to "disable" the default AliasMatch of ISPConfig.

 You only need to add to the Step 1 the following:

AliasMatch ^/users/(.*) /var/www/webX/web/users/$1

The complete code:

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<Directory /var/www/mydrupalwebsite.tld/web/> 
Options +Includes +FollowSymlinks -Indexes 
AllowOverride All 
Order allow,deny 
Allow from all 
<Files ~ "^\.ht"> 
Deny from all 
</Files> 
</Directory>
 
AliasMatch ^/users/(.*) /var/www/webX/web/users/$1

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 Hope this help you,

Ricardo.